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As aromatase inhibitor aminoglutethimide prevents the conversion of androgens to estrogens. It is used in medicine for the treatment of breast cancer, bodybuilders use it to counteract the side effects of anabolic steroid abuse. The drug aminoglutethimide was developed in the 60s as a drug for stroke. It was found to inhibit the function of the adrenal glands and thus the production of cortisone and androstenedione. Cortisone and androstendione are a precursor of testosterone, and are produced in the testicles. There is thus a potential antiandrogen which blocks not only the production of testosterone the testes, but also of the adrenal glands. Aminoglutethimide was the first aromatase inhibitor that has been used clinically. A disadvantage of aminoglutethimide is the undesired inhibition of cortisol production.
Nausea, diarrhea (diarrhea), vomiting, constipation, loss of appetite (anorexia), fever, sweating, rash (rash), drowsiness, decreased consciousness (lethargy). Side effects are common at the start of treatment, but usually disappear after about 6 weeks. You can be significantly reduced by creeping doses. Otherwise, the daily dose should be temporarily reduced: dizziness, disturbance of the orderly sequence of movements (ataxia). Headaches, depression, insomnia, confusion, inflammation of the liver (hepatitis from cholestatic type, connected to itchy skin rash), jaundice (jaundice).
Rare: dysfunction of the adrenal gland (hyponatremia, hypotension, dizziness, hypoglycemia), reduction in blood pressure (hypotension), hair loss, rash, muscle pain, and dyspepsia Compared with aminoglutethimide total letrozole caused fewer adverse effects. Aminoglutethimide caused frequent eruptions.
Application / dosage:
Bodybuilders use a maximum of 250mg / day at the end of a course of treatment discontinuation.
The dosage information given here are not as dosage recommendation or medical advice. These are details of bodybuilders who use these drugs or have used. The doses are to be regarded by no means as universally valid. If you’re thinking about steroids or use similar, ask a doctor or pharmacist.
Black market prices / availability:
Aminoglutethamid, aminoglutethimide, Aminoglutethamide
Trade name / manufacturer:
Cytadren / Novartis, USA
Orimeten / Novartis, Europe (2006 marketing Orimeten was set)
Mamonit / Pliva
Molecular formula: C13H16N2O2
Molecular Weight: 232.28 g / mol
Monoisotopic mass: 232.121185 Da
3- (4-aminophenyl) -3-ethyl-2,6-piperidinedione
3- (4-aminophenyl) -3-ethylazaperhydroine-2,6-dione