Androstenedione

This Post is also available in: German

Androstenedione is referred to as ProHormon because it is an intermediate product formed during testosterone and estrio-biosynthesis. The exact physiological function of androstenedione has not yet been fully investigated.

Androstenedione is a C-19 steroid belonging to the group of androgens (17-ketosteroid). It is a precursor of estron and testosterone.
Androstenedione is formed in the adrenal cortex and gonads, in men in the testes, in women in the follicles. In an adult male, the androstenedione is mainly formed in the testes, in the adult female in the half in the ovary and the adrenal.

Androstendion is on the doping list and has been banned by the IOC. It is used as a dietary supplement to increase performance in sports and bodybuilding.

The risk posed by androgen prohormones is that they are unambiguously attributed to drugs with a pharmacological effect, but are not detected either nationally or internationally as pharmaceuticals. These products are neither authorized as a food supplements nor as medicines in Germany and the sale is punishable.

Androstenedione, which is said to stimulate body-borne testosterone production, is a very popular dietary supplement in the US. Prohormones gained their popularity primarily through dehydroepiandrosterone (DHEA). Later, androstendione was praised as a miracle for performance enhancement, muscle growth and sexual enhancement. In contrast to Germany, androgens-prohormones are freely available in the USA.

Various studies – including manufacturers – were unable to establish a sustained increase in testosterone levels, no increase in muscle mass, and no increase in athletic performance.

A randomized double blind study by Sonntag et al. Revealed no significant effects of androstenedione on testosterone levels in 28-day men in middle age. A study of young men who also included strength training effects did not result in an increase in testosterone levels in eight weeks, nor did any increase in strength training effects.

In addition to the ineffectiveness on adaptation effects in force training, a possibly unfavorable reduction of the body’s testosterone synthesis could also be observed as a result of the androstenedione intake. The ineffectiveness of a sporting use the ratio of the risks caused by side effects gives a very unfavorable benefit / risk factor for the application in the sport.

The androstenedione plasma mirror may be affected by the following factors:

Elevated level: obesity, Cushing’s syndrome, androgen-producing tumors, ovarian stromal hyperthecosis, hirsmism, polycystic ovarian syndrome, virilizing congenital adrenal hyperplasia, 3β-hydroxysteroid dehydrogenase deficiency

Reduced levels: sickle cell anemia, adrenal insufficiency, ovarian failure

Side effects:

Possible reduction of HDL cholesterol levels and related cardiovascular risks, increased cardiovascular risk by increasing blood fat levels.

Possible favoring of the development of hormone-dependent tumors. Since androstenedione has not yet been sufficiently investigated in terms of long-term use, further side effects are possible.

Synonyms:

Androstenedion, Andro, Andros, ASD

Trade name / manufacturer:

Clearsynth Canada Inc. / Canada
SIGMA-ALDRICH Corporation / USA
Carbone Scientific Co., Ltd. / UK
Hangzhou J & H Chemical Co., Ltd. / China
Nebula Chemicals Co, Ltd. / China

Chemical information:

Molecular formula: C19H26O2
Molecular weight: 286,413 g / mol
Monoisotopic mass: 286.193268 Da

Androst-4-ene-3,17-dione
4-androstenedione
4-Androstene-3,17-dione
(1S,2R,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-ene-5,14-dione