Chorionic Gonadotropin

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Human chorionic gonadotropin, better known under the abbreviation HCG is a natural protein hormone that is formed in the mother cake (placenta) of a pregnant woman.

In the male, the Leydig cells are stimulated in the testes by the luteinizing hormone and stimulated to produce androgenic hormones (testosterone).

Steroids cause a negative feedback after a certain period of ingestion. There is an influence on the hypothalamic pituitary testicular axis because the hypothalamus receives a false signal which is caused by the steroids.

In bodybuilding, injectable HCG is used for increased testosterone production and is usually used in conjunction with anabolic / androgenic steroids. HCG is usually used at the end of a cure to counteract the side effects that are triggered by steroids.
Some bodybuilders occasionally use HCG during a steroid intake to counteract a testicular atrophy. Also, decreased libido and spermatogenicity caused by steroids can be successfully treated with HCG in most cases.

Side effects:

Vomiting, increased estrogen levels, gynecomastia, increased libido, more frequent erections, acne vulgaris,
Mood swings, increased blood pressure, morning sickness

In people who are still growing, HCG can lead to a premature closure of the growth joints of the bones, resulting in a reduced length growth.

Doping list:

The use of chorionic gonadotropin is generally prohibited in men.

Application / Dosage:

Each pack contains one ampoule per HCG vial containing an injection solution consisting of isotonic sodium chloride. This liquid is sterilely injected into the HCG ampoule and mixed with the dry substance after opening both ampoules. Then the solution is ready for injection and should be injected intramuscularly promptly. If only part of the mixture is injected at once, the rest should be kept in the refrigerator. The still unmixed HCG does not necessarily have to be stored in the refrigerator. However, it should be protected from light and kept at below 25 ° C.

In a study of 1980 (Padron et al.) It was found that the administration of an HCG injection with 6000 iE increased the testosterone level of the subject for six days. Further, it was found that a dose of 1500 i.E. The plasma testosterone level increased by 250-300% (2.5-3 fold), and at a dosage of 6000 i.E. The plasma testosterone level was even increased by 300-600% (3-6 fold) versus the initial value.

Based on these observations and general experience, bodybuilding has established itself as a rule of thumb, that the athlete every 5 days 2500 – 5000 i.E. Inject. A more frequent use than every 5 days is not necessary, as the testosterone level remains elevated for about 6 days.

The intake of HCG should be limited to a maximum of 3 weeks and be concluded with a subsequent break of at least one month.

The dosage information given here is not intended as a dosage recommendation or medical advice. These are statements by bodybuilders who have used or used these active ingredients. The dosages should never be regarded as generally valid. If you are using the idea of using steroids or similar, ask a doctor or pharmacist.

Black market prices / availability:

3 ampoules of chorionic gonadotropin, each 5000 i.E. Cost on the black market 30,00 – 45,00 Euro. Choriongonadotropin is readily available.


Gonadotrophinum chorionicum, human chorionic gonadotrophin, HCG, gonadotropic corionica, CG-beta, r-HCG, choriogonadotropin beta chain precursor

Trade name / manufacturer:

Prolan / Bayer
Pregnesin / Merck Serono
Pregnyl, Predalon / Organon AG

Chemical / biological information:

Molecular Formula: C1105H1770N318O336S26
Molecular weight: 25719.7 Da

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues each with N and O-linked carbohydrate moieties attached to ASN-52 and ASN-78 (alpha subunit) and ASN-13, ASN-30 SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha chain of r-hCG is identical to the alpha chain of hCG, FSH and LH.

Half-life: 8 hours.