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Cyproheptadine was developed as an antiallergic, but it turned out to stimulate appetite. It is now successfully used as an adjuvant in the control of bulimia (anorexia nervosa) because cyproheptadine is an antagonist of serotonin, a serotonin inhibitor. Without serotonin we become lethargic and get hot hunger. Because the body then gets the hormone over a detour. The more carbohydrates we eat, the more insulin is poured from the pancreas. Insulin provides for increased transport of tryptophan (a protein building block) into the brain and this is converted into serotonin. Without serotonin, there is no real sense of saturation.
Often, children who are “suffering from anorexia” are prescribed cyproheptadine.
The effect occurs after ingestion between 15 and 30 minutes and reaches its maximum of action after one hour. The overall effect lasts for 4 – 6 hours.
Drowsiness, dizziness, dyspnoea, gastrointestinal disturbance, premature menstrual bleeding, facial redness, urinary retention, muscle twitching, cardiac arrhythmia, convulsions, shock, respiratory depression , A dosage of over 32 mg should be avoided, as this can lead to hallucinations, central nervous depression and even to death.
Application / dosage:
In order to achieve an appetite increase, most manufacturers recommend 3 times daily a tablet of 4 mg cyproheptadine.
The dosage information given here is not intended as a dosage recommendation or medical advice. These are statements by bodybuilders who have used or used these active ingredients. The dosages should never be regarded as generally valid. If you are using the idea of using steroids or similar, ask a doctor or pharmacist.
Availability / Prices:
Cyproheptadine is prescription-only in Germany, and can be obtained from pharmacies. Price for 100 tablets of 4 mg are around 35,00 Euro.
Cyproheptadine hydrochloride, cyproheptadine hydrochloride, cyproheptadine hydrochloride, cyproheptadine, periactinol
Trade name / Manufacturer:
Peritol / Medphano Arzneimittel GmbH
Nuran syrup, Nuran BC-forte juice, tablets / MSD-Frosst Pharma
Periactinol tablets / MSD-Frosst Pharma
Nurdelin / ZAMBON GROUP SPA (Trademark owner)
Molecular formula: C21H21N
Molecular weight: 287.3981 g / mol
Monoisotopic mass: 287.167389 Da
4- (5H-dibenzo [a, d] cyclohepten-5-ylidene) -1-methylpiperidine
4- (5H-dibenzo [a, d]  annulen-5-ylidene) -1-methylpiperidine