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Piretanide is a loop diuretic, which causes an increased urinary excretion and can thereby excite a fluid accumulation of fluid in the tissue.

Piretanide relieves the heart and lowers the blood pressure and prevents the reabsorption of sodium into the Henle loop. This means that in the case of a low-salt diet the danger of hyponatremia is given. This situation is often given when bodybuilders prepare for a competition. The symptoms are loss of appetite, loss of strength and power, apathy and even coma. For this reason, a sufficient supply of NaCl (saline) must be observed when used.


Piretanide belongs to the active substance group of the loop diuretics. Like all drugs in this group, piretanide also blocks a protein in the kidneys, which ensures the return transport of water, sodium, potassium and chloride from the urine. This causes a strong urine flow through the excretion of fluid and minerals.

Piretanide is usually very well absorbed by the body and can therefore be administered with low doses.
In high doses, it causes, in addition to an increased excretion of water, a strong sodium excretion. The potassium and calcium outflows are lower.
But the sodium excretion is also dose-dependent. At low doses, as is customary, for example, for the treatment of hypertension, the sodium excretion does not differ very much from the natural one.

While the effervescent effect of piretanide usually occurs within the first hour after ingestion, and after 4 to 6 hours has elapsed, the antihypertensive effect slowly arises for one to two weeks.
A 24-hour sustained blood pressure reduction can thus be achieved with a single application per day.

Side effects:

Symptoms of the gastrointestinal tract, nausea, vomiting, digestive disorders, diarrhea, potassium deficiency, sodium deficiency, dehydration, erectile problems (due to blood pressure reduction), muscle cramps, circulatory collapse, dizziness, weakness

Pigment disturbances, especially in conjunction with solariums, are more frequently observed.


Piretandi should not be used in patients with severe renal failure (anuria), severe potassium deficiency (hypokalaemia), severe sodium deficiency (hyponatraemia), decreased circulating blood flow (hypovolaemia), hepatic coma or pre-coma. Do not use in diabetes.

Application / dosage:

Cardiac insufficiency and water retention are treated as standard with 6 mg of piretanide per day. High blood pressure is treated as a standard treatment at the beginning of the treatment with 2 tablets of 6mg of piretanide daily. As a so-called maintenance dose, ie after approximately 2 – 4 weeks, usually 6 mg of piretanide are sufficient per day.

Bodybuilders usually use a dosage of 6 mg piretanide per day to dehydrate.

The dosage information given here is not intended as a dosage recommendation or medical advice. These are statements by bodybuilders who have used or used these active ingredients. The dosages should never be regarded as generally valid. If you are using the idea of using steroids or similar, ask a doctor or pharmacist.


Piretanide, Piretanide-D4

Trade Name / Manufacturer:

Arelix / Aventis Pharma Germany GmbH
Piretanide Hexal / Hexal AG
Piretanix Sandoz / Sandoz Pharmaceuticals GmbH

Chemical information:Piretanid - Piretanide - Molekularformel

Molecular Formula: C17H18N2O5S
Molecular weight: 362.400 mg / mol
Monoisotopic mass: 362.093628 Da

4- (phenoxy) -3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid
Benzoic acid, 3- (aminosulfonyl) -4-phenoxy-5- (1-pyrrolidinyl) –
4-phenoxy-3- (1-pyrrolidinyl) -5-sulfamoylbenzoic acid